Duct leakage. Builder-grade duct connections in a 140-degree Phoenix attic fail eventually. When they do, you're paying to cool the attic. We covered the numbers in duct leakage and what it costs a Phoenix home.
Return capacity. A bigger system needs more air moving back to it. A return that was marginal with the old equipment can become genuinely restrictive with the new one.
Attic insulation. If the insulation above that one bedroom is thinner than the rest of the house, that room has a bigger cooling load than its neighbors — regardless of how good the AC is. More on that in attic insulation and air sealing.
Envelope leakage. Recessed lights, attic hatches, plumbing penetrations, and top plates all let conditioned air out and attic air in, one small opening at a time.